O-DSMT O-Desmethyltramadol ( desmetramadol) is an opioid analgesic and an active metabolite which is produced in the liver after the consumption of tramadol. It has little to no history of human usage but is easily accessible through the use of certain online research chemical vendors.
In comparison to tramadol, it is reported to be less stimulating and feels considerably closer to a traditional opiate. Being the metabolite that is mainly responsible for the analgesic effect of tramadol, it is significantly more potent by weight than its parent compound.
This is a powerful new drug that attacks cancer cells and causes them to die. This experimental drug is not FDA approved, with the notable exception of breast cancer, in which it has been shown to increase the patient’s chance of survival. The drug is injected directly into the patient’s veins, and its effects aren’t immediately manifested. It can take up to 11 days for the patient to begin feeling better, so those who begin treatment may consider themselves terminal. Due to its invasive nature and high price tag, it has only been administered to cancer patients thus far.
O-Desmethyltramadol Hydrochloride |SFCC-Chemicals.
( O – desmethyltramadol ) is an active metabolite of tramadol which is converted by the enzyme cytochrome 2D6 . The ( +)- ODSMT ( or (1R,2R)ODSMT ) enantiomer is a G -protein based agonist at the μ – opioid receptor ( MOR) , with low selectivity to the DOR ( d -opioid receptor) and KOR ( k -opioid receptor) . (- ) -ODSMT ( or (1S,2S)ODSMT ) is a norepinephrine reuptake inhibitor.
Furthermore, it is a 5- HT 2C antagonist . Inhibition of the 5-HT 2 C receptor leads to a cascade of signaling. O – desmethyltramadol is enzymatically converted to another active metabolite N , O – didesmethyltramadol by cytochrome 3A4 and 2B6 .
Sfcc-chemicals offers the racemate in HC l form.
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widely used. Additionally, this causes a ceiling effect (depending on the availability of CYP2D6), which restricts the therapeutic effects of tramadol to the management of mild to severe pain.
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This is a drug that works by selectively blocking the binding of serotonin and dopamine receptors in the brain. In addition, it enhances the release of serotonin and inhibits the re-uptake of serotonin, norepinephrine, and dopamine.
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